NFkB Signaling Pathway

Activation of NFκB pathway

Ligands and receptors: IL1B, IL8, MYD88, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF, TNFRSF10A, TNFRSF10B.

Membrane molecules: IRAK1, IRAK2. 山东大学齐鲁医院妇科张师前

Kinases: CHUK, IKBKB, IKBKG, IRAK1, IRAK2.

I-kappa-B kinase/NF-kappa-B cascade: EDARADD, IKBKG, IRAK2, STAT1, TLR8.

Cytoplasmic sequestering/releasing of NF-kappa-B: BCL3, IL10, NLRP12, NFKBIA, CD27 (TNFRSF7), TNFSF14.

Transcription factors: IKBKB, IKBKG, IRAK1, NFKB1, NFKBIA, RELA, STAT1, TNF.

Inflammatory response: IL1B, IL8, IRAK2, MYD88, NFKB1, TLR1, TLR2, TLR3, TLR4, TLR6, TLR8, TNF.

Positive regulation of I-kappa-B kinase/NF-kappa-B cascade

Ligands and receptors: CD40 (TNFRSF5), F2R, FASLG (TNFSF6), HTR2B, LTBR, SLC20A1, TICAM2, TNFRSF1A, TNFSF10, TICAM1 (TRIF).

Membrane molecules: EDG2, GJA1, HMOX1, RHOA.

Kinases: IKBKE, RIPK1, TBK1.

Other: BCL10, BIRC2, NOD1 (CARD4), CASP1, CASP8, CFLAR, SLC44A2 (CTL2), FADD, MALT1, PPM1A, REL, TRIM13 (RFP2), TMED4 (HNLF), TRADD.

NFκB Responsive Genes

Acute phase response proteins: AGT, CFB (BF).

Adhesion molecules: ICAM1.

Extracellular molecules: CFB (BF), CSF2, CSF3, IFNA1, IFNB1, IFNG, IL6.

Ligands and receptors: AGT, CCL2, ICAM1, LTA.

Cytokines: CCL2, CSF2, CSF3, IFNA1, IFNB1, IFNG, IL6, IL8, LTA, TNF.

Inflammatory response: CCL2.

Other factors involved in NF-kappa-B pathway

Extracellular molecules: IL1A.

Ligands and receptors: IL1R1, RAF1, TLR7, TLR9.

Kinases: AKT1, MAP3K1, RAF1.

Transcription factors: ATF1, EGR1, ELK1, FOS, JUN, NFKB2, RELB, TNFAIP3.

Inflammatory response: FOS, IL1A, IL1R1, TLR7, TLR9