TGFß BMP Signaling

TGF-β: TGFB1, TGFB2, TGFB3.

TGF-β Superfamily Cytokines:
BMP: BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7.

GDF: AMH, GDF2 (BMP9), GDF3 (Vgr-2), GDF5 (CDMP-1), GDF6, GDF7, IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), LEFTY1, LTBP1, LTBP2, LTBP4, NODAL, PDGFB. 山东大学齐鲁医院妇科张师前

Activin: INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), LEFTY1, NODAL.

Receptors: ACVR1 (ALK2), ACVR2A, ACVRL1 (ALK1), AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, ITGB5 (integrin B5), ITGB7 (integrin B7), LTBP1, NR0B1, STAT1, TGFB1I1, TGFBR1, (ALK5) TGFBR2, TGFBR3, TGFBRAP1.

SMAD: SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5).

SMAD Target Genes:
TGF-β/ Activin-Responsive: CDC25A, CDKN1A (p21WAF1 / p21CIP1), CDKN2B (p15LNK2B), COL1A1, COL1A2, COL3A1, FOS, GSC (goosecoid), IGF1, IGFBP3, IL6, ITGB5 (integrin B5), ITGB7 (integrin B7), JUN, JUNB, MYC, PDGFB, SERPINE 1 (PAI-1), TGFB1I1, TSC22D1 (TGFB1I4), TGFBI, TGIF1.

BMP-Responsive: BGLAP (osteocalcin), DLX2, ID1, ID2, JUNB, SOX4, STAT1.

Molecules Regulating Signaling of the TGF-β Superfamily: BAMBI, BMPER, CDKN2B (p15LNK2B), CER1 (cerberus), CHRD (chordin), CST3, ENG (Evi-1), EVI1, FKBP1B, FST (follistatin), HIPK2, NBL1 (DAN), NOG, PLAU (uPA), RUNX1 (AML1), SMURF1.

Adhesion and Extracellular Molecules:
Adhesion Molecules: BGLAP (osteocalcin), ENG (Evi-1), ITGB5 (integrin B5), ITGB7 (integrin B7), TGFB1I1, TGFBI.

Extracellular Matrix Structural Constituents: BGLAP (osteocalcin), COL1A1, COL1A2, COL3A1, LTBP1, LTBP2, LTBP4, TGFBI.

Other Extracellular Molecules: AMH, BMP1, BMP2, FST (follistatin), GDF2 (BMP9), GDF3 (Vgr-2), IGF1, IGFBP3, IL6, INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), PDGFB, PLAU (uPA), SERPINE1.

Transcription Factors and Regulators: DLX2, EVI1, FOS, GSC (goosecoid), HIPK2, ID1, JUN, JUNB, MYC, NR0B1, RUNX1 (AML1), SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SOX4, STAT1, TGFB1I1, TSC22D1 (TGFB1I4), TGIF1.

Genes Involving in Cellular and Developmental Processes:
Apoptosis: CDKN1A (p21WAF1 / p21CIP1), HIPK2, IGFBP3, INHA (inhibin a), INHBA (inhibin BA), STAT1, TGFB1.

Embryonic Development: BMP4, INHBA (inhibin BA), SMAD3, SMURF1.

Muscle Development: IGF1, SMAD3.

Neurogenesis: DLX2, INHA (inhibin a), INHBA (inhibin BA), NOG.

Reproduction: AMH, AMHR2, FST (follistatin), INHA (inhibin a), INHBA (inhibin BA), INHBB (inhibin BB), NR0B1.

Skeletal Development: BGLAP (osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD (chordin), COL1A1, COL1A2, IGF1, INHA (inhibin a), INHBA (inhibin BA), NOG.