Wnt Signaling Pathway

Frizzled-1 Signaling Pathway: AXIN1, DIXDC1, DVL1, DVL2, FZD3, FZD4, FZD6, FZD7, FZD8.

Frizzled-2 Signaling Pathway: WNT1, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT9A, WNT10A, WNT11, WNT16山东大学齐鲁医院妇科张师前

Regulation of Wnt Receptor Signaling Pathway:

Negative Regulation of Wnt Receptor Signaling Pathway: CXXC4, DKK1, FRZB (FRP-3), FSHB, NLK.

Wnt Binding Antagonists: SFRP1, SFRP4 (FRP-4).

Other Regulators of Wnt Signaling: PPP2CA, PPP2R1A, SENP2, TCF7L1.

Regulation of Growth and Proliferation:

Regulation of Growth: PPP2CA, PPP2R1A, WISP1.

Regulation of Cell Proliferation: CTBP1, CTBP2, LRP5.

Other Genes Related to Growth and Proliferation: FRAT1.

Regulation of the Cell Cycle: APC, CCND1, CCND2, CCND3, FGF4, PPP2CA, PPP2R1A.

Regulation of Transcription:

Transcription Factors: EP300, FOSL1 (Fra-1), FOXN1, JUN, MYC, PITX2, T (Brachyury), TCF7L1.

Other Regulators of Transcription: AES (TLE/ Groucho), CTNNB1 (catenin ?), CTNNBIP1 (ICAT), LEF1, NLK, PPP2CA, PPP2R1A, PYGO1, SOX17, TCF7 (Tcf-1), TLE1, TLE2, WNT1.

Protein Modification Activities:

Protein Kinase Activity: CSNK1A1, CSNK1D, CSNK1G1, CSNK2A1, CTBP1, GSK3A (GSKalpha), GSK3B (GSKbeta), NLK, WIF1.

Protein Phosphatase Type 2A Complex: PPP2CA, PPP2R1A.

Protein Ubiquitination: BTRC (b-TrCP), FBXW11, FBXW2, FBXW4.

Other Genes Related to Wnt Signaling: BCL9, FZD5 (FZD5), DAAM1, FZD1, FZD2, KREMEN1, LRP6, NKD1, PORCN, RHOU, SLC9A3R1.