灵芝破壁孢子粉抗癌活性的实验研究

 中华肿瘤防治杂志  目的:应用小鼠移植性肿瘤瘤株(S180),观察齐鲁 灵芝 破壁孢子 粉对荷瘤小鼠肿瘤生长的影响。方法:选择经腹腔和腋下接种小鼠肉瘤(S180)的昆明种小鼠为模型动物,经口灌胃齐鲁灵芝破壁孢子粉5、1.25和0.25g/kg(药/鼠质量)为实验组,以生理盐水经口灌胃为阴性对照,以环磷酰胺注射液腹腔注射为阳性对照。腹水瘤记录体质量增长和生存时间,实体瘤于荷瘤后14d处死小鼠,称取瘤块质量并计算抑瘤率。结果:腹水瘤组、实验组与阴性对照组体质量增长程度无差别,而阳性对照组体质量增长缓慢;阴性对照组的生存时间为(17±3.6)d,高、中、低实验组的生存时间分别为(23.5±7.5)、(22.75±4.5)和(20.8±2.2)d,生命延长率分别为38.2%、33.8%和22.4%。阳性对照组生存时间为(28.5±1.9)d。实体瘤组、阴性对照组的 实体瘤 质量为(1.25±0.28)g,高、中、低实验组的实体瘤质量分别为(0.675±0.38)、(0.875±0.24)和(1.075±0.47)g,抑瘤率分别为46.0%、30.0%和14.0%,阳性对照组实体瘤质量为(0.2±0.08)g,抑瘤率为84.0%。结...山东省肿瘤防治研究院肿瘤内科匡建民
    OBJECTIVE: To observe the antitumor effect of "gloosy ganoderma spores powder" on mice S180 tumor. METHODS: S180 tumor cells were inoculated into the abdominal cavities or subcutaneously in the right oxter of mice. The "gloosy ganoderma spores powder" was administrated orally in the experimented group of mice at the dose of 5 g/kg, 1.25 g/kg,0.25 g/kg. Saline group was taken as negative control and cyclophosphamide group as positive control. The animals were killed 14 days after inoculat...

文献名称	齐鲁灵芝破壁孢子粉抗癌活性的实验研究
Article Name 英文(英语)翻译	Studies on the antitumor effects of the glossy ganoderma spores powder;
作者	匡建民; 韩丽; 匡建梅; 黄海岩; 潘继红; 张忠玲;
Author	KUANG Jian-min1;HAN Li1;KUANG Jian-mei2;HUANG Hai-yan3;PAN Ji-hong4;ZHANG Zhong-ling41.Department of Oncology;Shandong Tumor Hospital;Jinan 250117;P.R.China 2.Department of Clinical Laboratory;Jiaozhou Center Hospital;Jiaozhou 266200;P.R.China 3.Department of Oncology;Jinan Overpass Area People Hospital;Jinan 250011;P.R.China 4.Shandong Medicinal Biotechnology Centre;Jinan 250062;P.R.China;
作者单位 Author Agencies	山东省肿瘤医院内科; 胶州中心医院检验科; 天桥区人民医院内科; 山东省医药生物技术研究中心; 山东省医药生物技术研究中心 山东济南; 山东济南; 山东胶州;
文献出处 Article From	中华肿瘤防治杂志;Chinese Journal of Cancer Prevention and Treatment;2007年 17期;
关键词	灵芝/药理学; 肿瘤; 实验性/免疫学; 孢子;
Keywords	ganoderma/pharmacology;neoplasms;experimental/immunologic;spores