高密度脂蛋白胆固醇水平与男性寿命延长有关

High HDL Cholesterol Linked to Long Life in Men

高密度脂蛋白胆固醇水平与男性寿命延长有关
Feb 24 - Men who reach their 85th birthdays tended to have high levels of HDL cholesterol while in their 60s, a new study says.

2月24日，一项新的研究显示，活到85以上的男性在60多岁时其高密度脂蛋白胆固醇水平较高。 海南医学院附属医院内分泌科王新军

Researchers found that men with the highest HDL cholesterol were 28% less likely to die before they reached 85, compared to men in the lowest HDL group.

研究人员发现，与高密度脂蛋白最低组男性相比，高密度脂蛋白胆固醇最高组男性在85岁之前死亡的风险减少28%。

This paper adds to the evidence that HDL is important for a long life, said Dr. Nir Barzilai, who heads the Institute for Aging Research at Albert Einstein College of Medicine in New York and was not part of the study.

本文为“HDL对于长寿是非常重要的”这一观点增加了新的证据，纽约阿尔伯特爱因斯坦医学院老化研究所主任Nir Barzilai博士说，他并没有参加本研究。

However, "we always have to remember that it"s an association," and it does not mean that having high HDL increases life span, he said.

然而，“我们必须记住，这是一种相关性”，这并不意味着高密度脂蛋白水平高就会延长寿命，他说。

The researchers, from the Massachusetts Veterans Epidemiology and Research Information Center in Boston, looked at the medical records of about 650 veterans when they were around 65 years old, then grouped them based on HDL levels.

来自波士顿马萨诸塞州退伍军人流行病学和研究信息中心的研究人员，观察了约650例退伍军人在65岁左右的医疗记录，然后根据高密度脂蛋白水平对他们进行分组。
Starting with low levels of 40 mg/dL, they found that for each ten mg/dL increase of HDL, the men were 14% less likely to have died by 85. Overall, 375 survived to that age.

他们发现，从40 mg/dL的较低水平开始，高密度脂蛋白每增加10 mg/dL，男性在85岁的死亡率减少14％。总体而言，有375人活到了85岁以上。

Also, fewer of the men with higher HDL were overweight, and they tended not to have more than 2 drinks a day. And fewer of them had heart disease or smoked, compared to the lowest HDL group.

此外，高密度脂蛋白较高的男性超重者较少，而且他们饮酒往往不会超过每天2个酒精单位。与高密度脂蛋白最低组相比，他们心脏病或吸烟者较少。

These other factors might have had an effect on survival, Dr. Barzilai said. However, the researchers did account for this, and still showed a link between reaching 85 and high HDL levels, he told Reuters Health.

这些其他因素可能对生存有一些影响，Barzilai博士说。然而，研究人员校正这些因素以后，仍然显示寿命在85岁以上与高密度脂蛋白水平相关，他告诉路透社健康频道记者。

"It"s difficult to change HDL levels," Dr. Barzilai said. Exercise might raise it a few points, but it isn"t a very efficient way to improve, he said. "We need to get a drug eventually."

“改变高密度脂蛋白胆固醇水平是非常困难的”， Barzilai博士说。运动或许可以提高几个百分点，但它不是一个非常有效的改善方法，他说。 “我们需要一种有效的药物”。

Merck and Roche are both working on an HDL raising drug, he told Reuters Health. Pfizer stopped its research into another such drug, torcetrapib, in 2006 because people taking it along with Lipitor in a study had a higher rate of death.

默克公司和罗氏公司都在致力于研制一种升高高密度脂蛋白胆固醇的药物，他告诉路透社记者。辉瑞公司在2006年停止了另外一种这类药物（torcetrapib）的研究，因为一项研究显示联合应用torcetrapib和立普妥的患者死亡率较高。

The B-vitamin niacin may raise HDL levels 15 to 35%. A three-month supply costs about nine dollars. Niacin is also found in dairy products, lean meats, nuts, eggs and fish.

B族维生素烟酸可提高高密度脂蛋白水平15至35％。服用3个月花费大约9美元。烟酸也存在于乳制品、瘦肉、坚果、蛋和鱼中。

However, it"s unclear how much raising HDL will prevent heart disease, Dr. Barzilai said, so whether drugs might improve people"s health remains to be seen.

不过，目前还不清楚需要提高多少高密度脂蛋白才可以预防心脏病，Barzilai博士说，因此是否药物会提高人们的健康状况仍然有待观察。

Am J Cardiol. Posted online February 4, 2011.