非侵入性检测动脉顺应性和踝臂指数的相关性：动脉粥样硬化多民族研究（MESA）

Associations of Noninvasive Measures of Arterial Compliance and Ankle-Brachial Index: The Multi-Ethnic Study of Atherosclerosis (MESA)

非侵入性检测动脉顺应性和踝臂指数的相关性：动脉粥样硬化多民族研究（MESA）海南医学院附属医院内分泌科王新军
The association between measures of arterial compliance and peripheral arterial disease (PAD) is unclear. Early changes in arterial wall compliance could be a useful marker of patients at high risk for developing lower extremity atherosclerosis.

动脉顺应性的检测和外周动脉疾病（PAD）之间的相关性尚不清楚。动脉壁顺应性的早期变化可能是下肢动脉粥样硬化高风险患者有用的标志。

We used linear and logistic regression models on baseline data from 2,803 female and 2,558 male participants in the Multi-Ethnic Study of Atherosclerosis (MESA) to study associations between tonometry-derived baseline measures of arterial compliance (large artery compliance (C1) and small artery compliance (C2)) and the baseline ankle-brachial index (ABI), as well as change in the ABI over ~3 years of follow-up.

作者对动脉粥样硬化多民族研究（MESA）受试者中的2,803例女性和2,558例男性使用线性和Logistic回归模型进行了分析。该研究观察了究张力测量衍生的基线动脉顺应性数值（大动脉顺应性C1和小动脉顺应性C2）和基线踝肱指数（ABI）以及ABI 3年随访变化之间的相关性。

In cross-sectional analyses, lower C1 and C2 values, indicating poorer arterial compliance, were associated with lower ABI. There were significant linear trends across strata of ABI, especially in C2 which ranged from 3.7 ml/mm Hg × 100 (95% confidence interval (CI) 3.3?4.2) in women with an ABI < 0.90 to 4.2 ml/mm Hg × 100 (95% CI 4.1?4.3 P < 0.001) in women with ABI 1.10? <1.40. Similar significant trends (P < 0.001) were seen in men. In prospective analyses, those with the lowest tertile of C2 values at baseline had a greater multivariable-adjusted odds for decline in ABI of ≥ 0.15 over 3 years compared to those with the highest C2 values at baseline (odds ratio (OR) 1.80).

在这项横断面分析中，较低的C1和C2的值（表示动脉顺应性较差）与较低的ABI相关。C2与ABI的分层存在显著的线性相关。前瞻性分析显示，与基线C2值最高的三分之一分位患者相比，基线C2值最低的三分之一分位的患者具有较大的ABI降低的风险（OR 1.80）。 

We observed that less compliant arteries were significantly associated with low ABI in cross-sectional analysis and with greater decline in odds of ABI over time.

本研究显示，在横断面分析中，较低的动脉顺应性与较低的ABI显著相关，随着时间的推移ABI降低的风险较大。