健康成人血管内皮功能与血清尿酸无关

Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults
健康成人血管内皮功能与血清尿酸无关

Some experimental evidence suggests that uric acid impairs endothelial function. It is controversial if high uric acid levels and impaired endothelial function are related in healthy adults. In addition, the effect of uric acid on endothelial cells (ECs) of humans is unexplored.海南医学院附属医院内分泌科王新军

一些研究提示尿酸会损害血管内皮功能。在健康成人高尿酸水平与血管内皮功能受损是否相关仍有争议。此外，尿酸对人血管内皮细胞（ECS）的影响仍不清楚。 

Data of 107 healthy adult volunteers were analyzed. The association between serum uric acid and endothelial-dependant dilation (EDD) and endothelial-independent dilation (EID) was evaluated by linear regression models. We also examined the relations between uric acid and systemic and cellular markers of inflammation and oxidative stress in all or subsets of participants.

本研究对107名健康成人志愿者的数据进行了分析。用线性回归模型评估了血清尿酸和内皮依赖性舒张功能（EDD）和内皮非依赖性舒张功能（EID）之间的相关性。同时观察了全部受试者和亚组中尿酸与全身及细胞炎症和氧化应激的相关性。 

Uric acid levels and EDD were not related in unadjusted or adjusted models. There was a significant negative correlation between uric acid and EID in the pooled sample (r = −0.34, P = 0.005). This correlation remained significant after adjusting for demographics (P = 0.04) and was attenuated after adjusting for other cardiac risk factors (P = 0.12). Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Serum uric acid levels were not associated with brachial artery EC nuclear factor-κB (NF-κB) p65 or NADPH oxidase p47phox expression or with nitrotyrosine staining, but were inversely associated with EC manganese superoxide dismutase (MnSOD) expression (r = −0.5, P = 0.01, n = 25).

结果显示，无论在未校正的模型还是校正后的模型，尿酸水平和EDD均无相关性。在合并样本中，尿酸和EID之间呈显著负相关。在校正人口学后这种相关性仍然显著，但在校正其他心血管危险因素后这种相关性减弱。高血清尿酸水平与C-反应蛋白（CRP）显著相关。血清尿酸水平与肱动脉EC核因子-κB（NF-kB）P65或NADPH氧化酶p47phox的表达，或硝基酪氨酸染色无相关性，但与EC锰超氧化物歧化酶（MnSOD）的表达呈负相关。 

Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation. These findings may have implications for cardiovascular risk in healthy adults.

血清尿酸升高与健康成人血管内皮功能障碍无关，但与EID和EC MnSOD呈负相关，与全身性炎症呈正相关。这些研究结果可能对健康成人的心血管风险具有一定意义。