AusDiab研究：看电视时间与5年葡萄糖稳态标志物呈负相关

Adverse associations of increases in television viewing time with 5-year changes in glucose homoeostasis markers: the AusDiab study.

AusDiab研究：看电视时间与5年葡萄糖稳态标志物呈负相关。

 Television viewing time is associated cross-sectionally with Background: abnormal glucose tolerance and diabetes risk; however, the impact of changes in television viewing time on glycaemic measures is less understood. We examined relationships of 5-year change in television  viewing time with 5-year change in glucose homeostasis markers. Methods: Participants in the Australian Diabetes, Obesity and Lifestyle study with data available at the 1999-2000 baseline and the 2004-2005 follow-up were included (4870; 45% men). Television viewing time (h/week) was assessed by questionnaire. Fasting plasma glucose, serum insulin and 2-h plasma glucose were obtained from an oral glucose tolerance test. Beta-cell function and insulin resistance were ascertained using the homeostasis model assessment 2-calculator. Associations of change in television viewing time with changes in glucose homeostasis markers were CI)]. 海南医学院附属医院内分泌科王新军

横断面研究显示看电视的时间与糖耐量异常和糖尿病的风险相关，但看电视时间的变化对血糖测定值的影响尚不清楚。作者研究了5年看电视时间的变化和5年葡萄糖稳态变化之间的关系。对在1999-2000年澳大利亚糖尿病、肥胖和生活方式研究受试者的基线数据和2004-2005年随访的数据进行了分析（4870例；45％为男性）。通过问卷调查对看电视的时间（小时/周）进行评估。测定空腹血糖、血清胰岛素和口服糖耐量试验2小时血糖。 β细胞功能和胰岛素抵抗采用稳态模型2计算器确定。看电视时间的变化与葡萄糖稳态标志物变化的相关性采用线性回归模型的β-系数统计。

Adjustments  included baseline measures of age, television viewing time and glycaemic marker, and baseline and 5-year change in diet quality, energy intake, physical activity  For every 5-h per week increase in television and waist circumference. Results: viewing time from baseline to 5-year follow-up, changes in glucose homeostasis markers were observed: among women there was a significant increase in fasting plasma glucose [0.01 (0.00-0.02) mmol/l] insulin resistance [0.03 (0.01-0.05)] and insulin secretion [1.07 (0.02-2.12) %]; insulin levels increased [men: 1.20 (0.30-2.09); women: 1.06 (0.32-1.80) pmol/l]; in men, 2-h plasma glucose levels  Five-year increases in increased [0.06 (0.01-0.1) mmol/l]. Conclusion: television viewing time were associated adversely with changes in glucose homeostasis markers. These findings add to earlier cross-sectional evidence that television viewing time can be associated with biomarkers of diabetes risk. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

校正因素包括基线年龄、看电视时间、血糖标志物，饮食质量的基线和5年的变化、能量摄入、体力活动和腰围。结果从基线到5年随访看电视的时间每增加5小时，其血糖标志物变化如下：在女性空腹血糖、胰岛素抵抗和胰岛素分泌显著增加；胰岛素水平在男性和女性均有增加；在男性中，2小时血糖水平显著上升。该研究提示5年看电视时间增加与葡萄糖稳态标志物的变化呈负相关。这些结果与以前的横断面研究证据一致：看电视的时间与糖尿病风险的生物标志物相关。