Interleukin-28B polymorphisms on the SVR in the treatment of naïve chronic hepatitis C with pegylated interferon-α plus ribavirin

il-28b基因多态性对慢性丙肝长效干扰素治疗的效果影响目前基本已有定论，从2009年nature genetics通过gwas技术确认该位点开始，全世界科研研究人员在该领域发表了大量有价值的论文，目前在国际上也开始在治疗前筛查il-28b基因多态性以指导临床治疗。这是我们团队最新在该方面进行的最为全面的信息整合报道，涉及各个病毒基因型以及人种，敬请关注！温州医学院附属第一医院感染内科郑明华

gene. 2012 jul 25. [epub ahead of print]
interleukin-28b polymorphisms on the svr in the treatment of naïve chronic hepatitis c with pegylated interferon-α plus ribavirin: a meta-analysis.
shi kq, liu wy, lin xf, fan yc, chen yp, zheng mh.
source
department of infection and liver diseases, liver research center, the first affiliated hospital of wenzhou medical college, wenzhou 325000, china; institute of hepatology, wenzhou medical college, wenzhou 325000, china.

abstract
there are accurate but inconclusive data on the association between single nucleotide polymorphisms (snps) of interleukin (il)-28b and sustained virological response (svr) in chronic hepatitis c (chc). this meta-analysis aimed to derive a more precise estimation of the effects of il-28b snps locus (rs12979860 and rs8099917) on svr in naïve chc patients receiving pegylated interferon alpha (peg-ifn-α) plus ribavirin. literature search was conducted up to june, 2011, in pubmed, embase and cochrane database of systematic reviews. a total of 36 studies involving 10912 cases with chc receiving peg-ifn-α plus ribavirin met the inclusion criteria. analyses were stratified either by ethnicity or genotype of hepatitis c virus. in genotype 1/4 patients, rs12979860 cc was associated with high svr in chc patients (caucasian: odds ratio (or), 4.567; 95% confidence interval (ci), 3.826-5.452; asian: or, 4.033; 95%ci, 3.050-5.333; african american: or, 4.297; 95%ci, 2.168-8.515; hispanics: or, 4.350; 95%ci, 2.817-6.717) but had no effect in genotype 2/3. in caucasian (genotype 1/4: or, 2.542; 95%ci, 2.108-3.065; genotype 2/3: or, 1.363; 95%ci, 1.020-1.820) and asian (genotype 1/4: or, 5.214; 95%ci, 3.694-7.360; genotype 2/3: or, 1.785; 95%ci, 1.095-2.910), rs8099917 tt was associated with high svr in both genotype 1/4 and 2/3. meta-regression showed that in caucasians with chc genotype 1/4, gender male might contribute to the effect of rs12979860 on svr but advanced fibrosis might weaken this effect. furthermore, in asians with chc genotype 1/4, high baseline viral load and advanced fibrosis might also undermine the effect of rs8099917 on svr. this meta-analysis suggested that il-28b rs12979860 cc and rs8099917 tt were associated with high svr rate in chc genotype 1/4. in chc genotype 2/3, rs8099917 tt carriers also had higher svr.

crown copyright © 2012. published by elsevier b.v. all rights reserved.

pmid: 22842190