Liver tissue engineering: promises and prospects of new technology

陈永平教授研究团队最新肝组织工程方面的综述兼述评，刚发表后就收到国际同行来信咨询相关细节及索要PDF原件。

Cytotherapy. 2010 May;12(3):349-60.

Zheng MH, Ye C, Braddock M, Chen YP.

Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.温州医学院附属第一医院感染内科郑明华

 

Today, many patients suffer from acute liver failure and hepatoma. This is an area of high unmet clinical need as these conditions are associated with very high mortality. There is an urgent need to develop techniques that will enable liver tissue engineering or generate a bioartificial liver, which will maintain or improve liver function or offer the possibility of liver replacement. Liver tissue engineering is an innovative way of constructing an implantable liver and has the potential to alleviate the shortage of organ donors for orthotopic liver transplantation. In this review we describe, from an engineering perspective, progress in the field of liver tissue engineering, including three main aspects involving cell sources, scaffolds and vascularization.