白介素8-251位点基因多态性与我国高低发区胃癌关系

 曾志荣　 周韶璋　 廖山婴　 陈斌　 李初俊　 陈?湖　 胡品津　

Correlation of Polymorphism of Interleukin 8 Gene-251 Locus and Gastric Cancer in High and Low Prevalence Regions in China  ZENG Zhi-rong　 ZHOU Shao-zhang　 LIAO Shan-yin　 CHEN Bin　 LI Chu-jun　 CHEN Min-hu　 HU Pin-jin中山大学附属第六医院消化内镜中心李初俊

 

摘　要：

[目的]研究白介素(interleukin,IL)-8基因-251A/T位点多态性在中国高、低发区普通人群和胃癌(gastric cancer,GC)患者中的分布,并探讨其基因多态性与我国胃癌的关系.

[方法]用聚合酶链反应-反向杂交法(polymerase chain reaction and reverse dot blot,PCR-RDB)检测我国胃癌低发区(广东省)104例健康人和104例胃癌患者和胃癌高发区(陕西省)102例健康人和102例胃癌患者的IL-8基因-251A/T位点多态性.

[结果]在胃癌低发区,胃癌患者IL-8-251 A/A基因型的频率略高于正常对照组,但未达统计学意义(27.9% vs 21.2%,x2=1.27,P＞0.05),胃癌患者携带IL-8-251 A/A基因型不增加Hp感染后胃癌发生的危险性(x2=1.40,P＞0.05),而在胃癌高发区,胃癌患者携带IL-8-251 A/A的频率明显高于普通人群(31.2% vs 16.7%,x2=6.04,P＜0.05,OR=2.29,95%CI=1.17-4.46),并增加Hp感染后胃癌发生的危险性(x2=6.38,P＜ 0.05,OR=4.71,95%CI=1.36-16.30).

[结论]IL-8-251A等位基因与我国汉族人群胃癌的发生相关,以高发区明显.

 

基金项目：广东省医学科研基金资助项目(2002176)

 

---中山大学学报（医学科学版）   

JOURNAL OF SUN YAT-SEN UNIVERSITY(MEDICAL SCIENCES)
2005 Vol.26 No.5 P.537-540

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