Intracellular chemotherapeutic agents/antineoplastic agents (L01)

[hide] v • d • eIntracellular chemotherapeutic agents/antineoplastic agents (L01) SPs/MIs (M phase)Block microtubule assemblyVinca alkaloids (Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine) Block microtubule disassemblyTaxanes (Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel) ? Epothilones (Ixabepilone) DNA replication inhibitorDNA precursors/ antimetabolites (S phase)Folic aciddihydrofolate reductase inhibitor (Aminopterin, Methotrexate, Pemetrexed) ? thymidylate synthase inhibitor (Raltitrexed, Pemetrexed) Purineadenosine deaminase inhibitor (Pentostatin) halogenated/ribonucleotide reductase inhibitors (Cladribine, Clofarabine, Fludarabine) thiopurine (Thioguanine, Mercaptopurine) Pyrimidinethymidylate synthase inhibitor (Fluorouracil, Capecitabine, Tegafur, Carmofur, Floxuridine) DNA polymerase inhibitor (Cytarabine) ribonucleotide reductase inhibitor (Gemcitabine) hypomethylating agent (Azacitidine, Decitabine) Deoxyribonucleotideribonucleotide reductase inhibitor (Hydroxyurea) Topoisomerase inhibitors (S phase)ICamptotheca (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan) IIPodophyllum (Etoposide, Teniposide) II+IntercalationAnthracyclines (Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Valrubicin, Zorubicin) ? Anthracenediones (Mitoxantrone, Pixantrone) Crosslinking of DNA (CCNS)AlkylatingNitrogen mustards: Mechlorethamine ? Cyclophosphamide (Ifosfamide, Trofosfamide) ? Chlorambucil (Melphalan, Prednimustine) ? Bendamustine ? Uramustine ? Estramustine Nitrosoureas: Carmustine ? Lomustine (Semustine) ? Fotemustine ? Nimustine ? Ranimustine ? Streptozocin Alkyl sulfonates: Busulfan (Mannosulfan, Treosulfan) Aziridines: Carboquone ? ThioTEPA ? Triaziquone ? Triethylenemelamine Alkylating-likePlatinum (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) NonclassicalHydrazines (Procarbazine) ? Triazenes (Dacarbazine, Temozolomide) ? Altretamine ? Mitobronitol IntercalationStreptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) Photosensitizers/PDTAminolevulinic acid/Methyl aminolevulinate ? Efaproxiral ? Porphyrin derivatives (Porfimer sodium, Talaporfin, Temoporfin, Verteporfin) OtherEnzyme inhibitorsFI (Tipifarnib) ? CDK inhibitors (Alvocidib, Seliciclib) ? PrI (Bortezomib) ? PhI (Anagrelide) ? IMPDI (Tiazofurine) ? LI (Masoprocol) Receptor antagonistsERA (Atrasentan) ? retinoid X receptor (Bexarotene) ? sex steroid (Testolactone) Other/ungroupedAmsacrine ? Trabectedin ? retinoids (Alitretinoin, Tretinoin) ? Arsenic trioxide ? asparagine depleter (Asparaginase/Pegaspargase) ? Celecoxib ? Demecolcine ? Elesclomol ? Elsamitrucin ? Etoglucid ? Lonidamine ? Lucanthone ? Mitoguazone ? Mitotane ? Oblimersen ? Temsirolimus ? Vorinostat