Pulse pressure is an independent risk factor for stroke amongmiddle-aged Japanese with normal systolic blood pressure

the JPHC study

Results Pulse pressure was positively associated with risk of stroke as was systolic and diastolic blood pressures. The multivariable hazard ratio of total stroke associated with a 1- SD increment (13.2mmHg) of pulse pressure was 1.14(1.05?1.24). The excess risk was observed for the stratumof systolic blood pressure below 140mmHg, but not of higher systolic blood pressure levels after adjustment for diastolic blood pressure and other potential confounding factors; the multivariable hazard ratio of stroke associated烟台毓璜顶医院神经内科梁志刚
with a 1-SD increment of pulse pressure was 1.32 (1.07? 1.64) among persons with normal systolic blood pressure levels.

Pulse pressure is a risk factor for stroke among normotensive individuals with systolic blood pressure below 140 mmHg, which suggests that pulse pressure may be useful to predict the risk of stroke amongmiddle-aged nonsystolic hypertensive patients