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- 谢道俊主任医师
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医院:
安徽中医药大学第一附属医院
科室:
脑病科
- 血管性痴呆
- 作者:谢道俊|发布时间:2012-02-25|浏览量:462次
黄蒲通窍胶囊对血管性痴呆患者血清SS、AVP的影响及疗效评价
【摘要】 目的: 通过观测黄蒲通窍胶囊对VaD患者智能量表的影响,检测血清中生长抑素(SS)、精氨酸加压素(AVP)的含量变化,来评价中药复方黄蒲通窍胶囊对VaD患者的疗效,并探讨黄蒲通窍胶囊对VaD患者的治疗作用及机理,阐明药物作用途径。方法:选择VaD患者60 例,随机分为治疗组(30人)和对照组(30人); 治疗组在内科基础治疗的同时服用黄蒲通窍胶囊,对照组在内科基础治疗的同时服用喜得镇,两组在治疗前和治疗后均采用简易智能状态检查表(MMSE)、老年性痴呆评定量表-认知分量表(ADAS-cog)、日常生活能力量表(ADL)的测定来进行疗效评价以及测定患者血清中SS、AVP的含量。结果:与对照组比较,治疗组血清中SS、AVP的含量显著提高,与对照组比较均存在明显差异(P<0.05)。结论: 通过对血管性痴呆患者的临床评价可以看出黄蒲通窍胶囊具有改善患者记忆和认知功能的作用,VaD患者血清中SS、AVP的含量较低,黄蒲通窍胶囊能有效提高患者血清中SS、AVP的含量,其作用机制可能与提高SS、AVP神经肽含量有关。安徽省中医院脑病科谢道俊
关键词 血管性痴呆 黄蒲通窍胶囊 记忆和认知功能 生长抑素 精氨酸加压素
Objective: To observe the intelligence scale status in patient with Vascular dementia ,detect in serum SS, AVP content and analyze the effect mechanism of Huang Po Tongqiao Capsule for the treatment of VaD。Methods: 60 patients were consistent with the VaD diagnostic criteria。60 patients were randomly devided into two groups including Huang Po Tongqiao Capsule trial group (n=30) and hydergine control group(n=30),the therapy lasts for 3 months(12 weeks)。Calculate MMSE、ADAS-cog 、ADL、SS、AVP concentrations before and after the therapy。Conclusions: Through the treatment of vascular dementia patients with clinical evaluation,we can see that Huang Po Tongqiao Capsule has improed memory and cognitive function。The serum AVP and SS content of VaD patients is lower than that in healthy people, Huang Po Tongqiao Capsule can efficaciously improve the content SS and AVP in serum of patient。
Key words: Vascular dementia 、 Huang Po Tongqiao capsules 、 Memory and cognitive function、 SS 、 AVP