乌司他丁在重型颅脑损伤中的应用价值研究

引用本文：	张银清,陈汉民,廖圣芳,王文鑫,余锦刚.乌司他丁在重型颅脑损伤中的应用价值研究[j].临床军医杂志,2005,33(6):697-698.
作者姓名：	张银清  陈汉民  廖圣芳  王文鑫  余锦刚
作者单位：	解放军第180医院神经外科,福建泉州362000
摘    要：	目的 探讨乌司他丁对重型颅脑损伤疗效、对血浆内皮素（et）水平的影响及其意义。方法 对人选的83例伤后6h人院重型脑损伤（gcs〈8分）患者，在常规综合治疗基础上随机分为两组，乌司他丁治疗组41例，每天20万单位加入生理盐水30ml微泵静注，2次／d。以42例同等伤情未用乌司他丁治疗病例为对照组，于治疗后24h、72h、7d采用特异性放射免疫分析法测定血浆中et含量。结果 治疗前两组病人血浆et含量均较正常明显升高，治疗后24h两组患者血浆et水平均下降，于第3天，7天治疗组et值明显低于对照组p〈0．05）；治疗后第7天，治疗组血浆et值接近正常（p〉o．05）。治疗组病死率明显低于对照组（p〈0．05）。结论 乌司他丁可以降低重型颅脑损伤早期血浆内皮素的水平，降低消化道出血发生率，改善预后。晋江市中医院脑外科张银清
关 键 词：	重型颅脑损伤  乌司他丁  血浆内皮素  疗效
文章编号：	1671-3826（2005）06-0697-02
收稿时间：	2005-10-11
修稿时间：	2005年10月11
作者简介：	发表论文50余篇，目前主要从事颅脑损伤的临床研究。
study on applicative value of uinastation in severe cerebral trauma
zhang yin-qing, chen han-min, liao sheng-fang, wang wen-xin, yu jin-gang.study on applicative value of uinastation in severe cerebral trauma[j].clinical journal of medical officer,2005,33(6):697-698.
authors:	zhang yin-qing  chen han-min  liao sheng-fang  wang wen-xin  yu jin-gang
abstract:	objective to discuss the effect of uinastation on severe cerebral trauma and its influence on plasm endothelin(et)methods eighty-three patients,who were admitted to the hospital within six hours after they had suffered from cerebral trauma with glasgow coma score(gcs) lower than 8,were enrolled in the study.on the basis of routine treatment,they were divided into uinastation group(41) and control group(42) at random.additionally,the former group was intravenously administered uinastation(200,000u) added to normal saline twice per day.then,their plasm et levels were respectively measured 24 hours,72 hours and seven days later after treatment.results the et levels of the two groups were higher than that of normal reference value,but they went down 24 hours later after treatment.furthermore,the et level of the uinastation group was significantly lower than that of the control group 72 hours or seven days later after treatment(p<0.05).the uinastation group"s et level went down to normal after seven days.in the end,the death rate of the uinastation group was also significantly lower than that of the control group(p<0.05).as for digestive bleeding,the lower bleeding rate was found in the the uinastation group(p<0.05).conclusion uinastation is effective on lowering plasm et level and digestive bleeding rate of severe cerebral trauma at early stage.
keywords:	severe cerebral trauma  uinastation  plasm endothelin