- 泽菲联合盖诺治疗不能耐受顺铂晚期非小细胞肺癌临床观察
- 作者：陈群|发布时间：2013-06-21|浏览量：686次
gemcitabine plus vinorelbine for treatment of unendurable cisplatinum-based chemotherapy in advanced non-small cell cancer
推荐 caj下载 pdf下载 福州肺科医院呼吸内科陈群
【作者】陈群; 李育宏; 石琴; 谢强; 陈雨燕; 王成辉; 王琳
【author】chen qun; li yu-hong; si qing; et al. (fuzhou pulmonary hospital; fuzhou 350008; china)
【作者机构】福建医科大学教学医院福州肺科医院 福建福州350008
【摘要】 [目的]评价泽菲联合盖诺治疗不能耐受顺铂的晚期非小细胞肺癌的疗效和毒性。[方法]108例?和?期非小细胞肺癌既往均未曾放疗或化疗,ecog评分≤2,生存期超过3个月,wbc计数>4.0×109/l,肝、肾功能生化指标正常,未有活动性感染征象。36例以泽菲联合盖诺(gn)为一线方案,另外36例以吉西他滨加顺铂(gp),还有36例以长春瑞滨加顺铂(np)为一线方案作对照组。[结果]gp组、np组和gn组rr分别为44.44%、43.24%和33.33%,三组疗效无统计学差异(p>0.05)。gn组与另两组在?～?度血液学毒性方面比较无统计学差异(p>0.05);gn组非血液学毒性比较少(p<0.01)。[结论]gn方案疗效较好,毒性较低,尤其适合于不能耐受顺铂的晚期nsclc患者。
【abstract】 purpose to evaluate the efficacy and toxicity of gemcitabine plus vinorelbine in the treatment of unendurable cisplatinum-based chemotherapy in advanced non-small cell cancer(nsclc).methods one hundred and eight cases with advanced nsclc staging ? and ?,with ecog score ≤2 point,survival time more than three months,counts of wbc >4.0×109/l,unnormal function of liver and kidney and no infection symptom were divided into three groups.all patients treated previously without radiotherapy and chemotherapy,36 of those patients were treated with gemcitabine plus vinorelbine(gn group),another 36 cases with gemcitabine plus cisplatin(gp group),and 36 cases with vinorelbine plus cisplatin(np group,control group).results the response rates(rr)were 44.44% in gp group;43.24%,np group;and 33.33%,gn group.there was no significant difference in rr among three groups(p>0.05).there was no significant difference in toxicity of ?～? degree haematology between gn group and the another two groups(p>0.05)while less toxicity of non-haematology in gn group(p<0.01).conclusion gn regimen is better regimen with lower toxicity.it may be suitable for the a advanced nsclc with unendurable cisplatinum-based chemotherapy.
【关键词】 非小细胞肺癌; 药物疗法; 吉西他滨; 长春瑞滨
【key words】 non-small cell cancer; drug therapy; gemcitabine; vinorelbine
【文献出处】 中国肿瘤,bulletin of chinese cancer,编辑部邮箱,2007年08期
【doi】cnki:sun:zhlu.0.2007-08-014
【分类号】r734.2
【下载频次】25
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推荐 caj下载 pdf下载 福州肺科医院呼吸内科陈群
【作者】陈群; 李育宏; 石琴; 谢强; 陈雨燕; 王成辉; 王琳
【author】chen qun; li yu-hong; si qing; et al. (fuzhou pulmonary hospital; fuzhou 350008; china)
【作者机构】福建医科大学教学医院福州肺科医院 福建福州350008
【摘要】 [目的]评价泽菲联合盖诺治疗不能耐受顺铂的晚期非小细胞肺癌的疗效和毒性。[方法]108例?和?期非小细胞肺癌既往均未曾放疗或化疗,ecog评分≤2,生存期超过3个月,wbc计数>4.0×109/l,肝、肾功能生化指标正常,未有活动性感染征象。36例以泽菲联合盖诺(gn)为一线方案,另外36例以吉西他滨加顺铂(gp),还有36例以长春瑞滨加顺铂(np)为一线方案作对照组。[结果]gp组、np组和gn组rr分别为44.44%、43.24%和33.33%,三组疗效无统计学差异(p>0.05)。gn组与另两组在?～?度血液学毒性方面比较无统计学差异(p>0.05);gn组非血液学毒性比较少(p<0.01)。[结论]gn方案疗效较好,毒性较低,尤其适合于不能耐受顺铂的晚期nsclc患者。
【abstract】 purpose to evaluate the efficacy and toxicity of gemcitabine plus vinorelbine in the treatment of unendurable cisplatinum-based chemotherapy in advanced non-small cell cancer(nsclc).methods one hundred and eight cases with advanced nsclc staging ? and ?,with ecog score ≤2 point,survival time more than three months,counts of wbc >4.0×109/l,unnormal function of liver and kidney and no infection symptom were divided into three groups.all patients treated previously without radiotherapy and chemotherapy,36 of those patients were treated with gemcitabine plus vinorelbine(gn group),another 36 cases with gemcitabine plus cisplatin(gp group),and 36 cases with vinorelbine plus cisplatin(np group,control group).results the response rates(rr)were 44.44% in gp group;43.24%,np group;and 33.33%,gn group.there was no significant difference in rr among three groups(p>0.05).there was no significant difference in toxicity of ?～? degree haematology between gn group and the another two groups(p>0.05)while less toxicity of non-haematology in gn group(p<0.01).conclusion gn regimen is better regimen with lower toxicity.it may be suitable for the a advanced nsclc with unendurable cisplatinum-based chemotherapy.
【关键词】 非小细胞肺癌; 药物疗法; 吉西他滨; 长春瑞滨
【key words】 non-small cell cancer; drug therapy; gemcitabine; vinorelbine
【文献出处】 中国肿瘤,bulletin of chinese cancer,编辑部邮箱,2007年08期
【doi】cnki:sun:zhlu.0.2007-08-014
【分类号】r734.2
【下载频次】25
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