高压氧治疗依据

由于学科专业等方面的差异，部分同道对高压氧的治疗效果存在疑虑，现列举国外文献说明：

 1、  无论高压氧还是常压氧对创伤性脑损伤、缺血缺氧性脑损害、卒中都有相当疗效：主要通过改善供氧、抑制缺血再灌注损伤、减轻线粒体损伤、减少脑脊液分泌、抑制兴奋性氨基酸释放、调节白介素6、8等因子分泌、降低热休克蛋白32水平、促进骨髓干细胞释放等机制；而肺、脑、眼等器官的副损伤很小！广州军区总医院高压氧科谢秋幼

2、  高压氧效果强于常压氧但不等于常压氧无效！

3、  延迟的高压氧干预无效，但也未发现明显副损伤！所以强调早期介入！

文  献：

1. Rockswold,-S-B; Rockswold,-G-L; Zaun,-D-A; et al. A prospective, randomized clinical trial  to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism,  intracranial pressure, and oxygen toxicity in severe traumatic brain injury.  J-Neurosurg. 2010 May; 112(5): 1080-94.

2. Yang,-Z-J; Xie,-Y; Bosco,-G-M; et al. Hyperbaric oxygenation alleviates MCAO-induced   brain injury and reduces hydroxyl radical formation and glutamate release.  Eur-J-Appl-Physiol. 2010 Feb; 108(3): 513-22。

3. Kumaria,-A; Tolias,-C-M. Normobaric hyperoxia therapy for traumatic brain injury and   stroke: a review. Br-J-Neurosurg. 2009 Dec; 23(6): 576-84.

4．Lin,-J-W; Tsai,-J-T; Lee,-L-M; et al. Effect of hyperbaric oxygen on patients with traumatic   brain injury. Acta-Neurochir-Suppl. 2008; 101: 145-9

5. Jadhav,-V; Ostrowski,-R-P; Tong,-W; et al. Cyclo-oxygenase-2 mediates hyperbaric oxygen   preconditioning-induced neuroprotection in the mouse model of surgical brain injury.  Stroke. 2009 Sep; 40(9): 3139-42.

6. Milovanova,-T-N; Bhopale,-V-M; Sorokina,-E-M; Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo.   J-Appl-Physiol. 2009 Feb; 106(2): 711-28.