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- 刘玉金_(附)副主任医师 副教授
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医院:
上海中医药大学附属岳阳中西医结合医院
科室:
放射介入科
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- Preoperative combined with postoperative transcatheter arterial chemoembolization can improve survival in patients with hepatocellular carcinoma: a single-center study.
- 作者:刘玉金_(附)|发布时间:2010-07-14|浏览量:669次
J Vasc Interv Radiol 2009; 20:472?483
PURPOSE: To assess the role of combined preoperative and postoperative chemoembolization in patients with resectable hepatocellular carcinoma (HCC).
MATERIALS AND METHODS: Outcomes were retrospectively analyzed in 281 consecutive patients who underwent hepatectomy for HCC between January 1995 and December 2006. Of the 281 patients, 118 patients did not undergo chemoembolization and served as controls; the remaining 163 patients underwent chemoembolization preoperatively, postoperatively, or both. The chemoembolization group was categorized into three subgroups: patients who underwent postoperative chemoembolization (group A, n 86), those who underwent preoperative chemoembolization (group B, n 37), and those who underwent pre- and postoperative chemoembolization (group C, n 40). The patients’ survival rates were analyzed上海第十人民医院介入科刘玉金
with Kaplan-Meier survival curves and compared by the log-rank test. Factors related to survival rate were evaluated by univariate and multivariate analysis.
RESULTS: Patient characteristics were similar in the two groups and three subgroups. Group C had a significantly higher survival rate compared with the nonchemoembolization group or group A (both P .008). Survival rates in groups A and B were not significantly better than that of the nonchemoembolization group (both P > 0.05). According to multivariate analysis, microscopic vascular invasion and -fetoprotein (AFP) level were independent prognostic factors.
CONCLUSIONS: Combined preoperative and postoperative chemoembolization, when performed as an adjuvant treatment, may increase the survival rate of patients with resectable HCC, especially for patients with microscopic vascular invasion and high AFP levels.
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